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Information transfer from peptide nucleic acids to RNA by template-directed synthesesPeptide nucleic acids (PNAs) are uncharged analogs of DNA and RNA in which the ribose-phosphate backbone is substituted by a backbone held together by amide bonds. PNAs are interesting as models of alternative genetic systems because they form potentially informational base paired helical structures. A PNA C10 oligomer has been shown to act as template for efficient formation of oligoguanylates from activated guanosine ribonucleotides. In a previous paper we used heterosequences of DNA as templates in sequence-dependent polymerization of PNA dimers. In this paper we show that information can be transferred from PNA to RNA. We describe the reactions of activated mononucleotides on heterosequences of PNA. Adenylic, cytidylic and guanylic acids were incorporated into the products opposite their complement on PNA, although less efficiently than on DNA templates.
Document ID
20040172810
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Schmidt, J. G.
(The Salk Institute for Biological Studies PO Box 85800, San Diego, CA 92186, United States)
Nielsen, P. E.
Orgel, L. E.
Bada, J. L.
Date Acquired
August 22, 2013
Publication Date
December 1, 1997
Publication Information
Publication: Nucleic acids research
Volume: 25
Issue: 23
ISSN: 0305-1048
Subject Category
Exobiology
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Exobiology
Non-NASA Center

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