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Biochemical markers in the assessment of bone diseaseAs the mean age of our population increases, increasing attention has been paid to the diseases associated with aging, including diseases of the skeleton such as osteoporosis. Effective means of treating and possibly preventing such skeletal disorders are emerging, making their early recognition an important goal for the primary care physician. Although bone density measurements and skeletal imaging studies remain of primary diagnostic importance in this regard, a large number of assays for biochemical markers of bone formation and resorption are being developed that promise to complement the densitometry measurements and imaging studies, providing an assessment of the rates of bone turnover and an earlier evaluation of the effects of therapy. In this review, emphasizing the recent literature, the major biochemical markers currently in use or under active investigation are described, and their application in a number of diseases of the skeleton including osteoporosis is evaluated.
Document ID
20040172836
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Bikle, D. D.
(University of California and Veterans Administration Medical Center San Francisco 94121, United States)
Date Acquired
August 22, 2013
Publication Date
November 1, 1997
Publication Information
Publication: The American journal of medicine
Volume: 103
Issue: 5
ISSN: 0002-9343
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: DK28116
Distribution Limits
Public
Copyright
Other
Keywords
Review
Non-NASA Center
Review, Tutorial
NASA Discipline Musculoskeletal

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