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Effects of exercise on knee joints with osteoarthritis: a pilot study of biologic markersOBJECTIVE: To determine the effects of low intensity weight-bearing exercise on osteoarthritis (OA) of the knee. METHODS: Synovial fluid keratan sulfate (KS) and hydroxyproline were measured as markers of cartilage degradation. The Arthritis Impact Measurement Scales (AIMS) were used to measure health status, and a visual analog scale for pain assessment was used before and after intervention. An exercise (EX) group (n = 15) received a thrice-weekly 12-week low intensity exercise program and a weekly educational program, and a minimal treatment (Min RX) group (n = 15) received only the education program. RESULTS: Pain levels declined in the EX group, and the Min RX group showed improvement on the AIMS. Synovial fluid was obtained in 11 subjects before and after the intervention. Levels of KS and hydroxyproline did not change. CONCLUSION: Further study of exercise effects should include both clinical and biologic parameters to examine the outcome of exercise as a therapeutic intervention in OA of the knee.
Document ID
20040172896
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Bautch, J. C.
(University of Wisconsin-Madison, School of Nursing 53792-2455 United States)
Malone, D. G.
Vailas, A. C.
Date Acquired
August 22, 2013
Publication Date
February 1, 1997
Publication Information
Publication: Arthritis care and research : the official journal of the Arthritis Health Professions Association
Volume: 10
Issue: 1
ISSN: 0893-7524
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal

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