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Protein phosphatase 2A in stretch-induced endothelial cell proliferationWe previously proposed that activation of protein kinase C is a key mechanism for control of cell growth enhanced by cyclic strain [Rosales and Sumpio (1992): Surgery 112:459-466]. Here we examined protein phosphatase 1 and 2A activity in bovine aortic endothelial cells exposed to cyclic stain. Protein phosphatase 2A activity in the cytosol was decreased by 36.1% in response to cyclic strain for 60 min, whereas the activity in the membrane did not change. Treatment with low concentration (0.1 nM) of okadaic acid enhanced proliferation of both static and stretched endothelial cells in 10% fetal bovine serum. These data suggest that protein phosphatase 2A acts as a growth suppressor and cyclic strain may enhance cellular proliferation by inhibiting protein phosphatase 2A as well as stimulating protein kinase C.
Document ID
20040173097
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Murata, K.
(Yale University School of Medicine New Haven, Connecticut 06510, United States)
Mills, I.
Sumpio, B. E.
Date Acquired
August 22, 2013
Publication Date
December 1, 1996
Publication Information
Publication: Journal of cellular biochemistry
Volume: 63
Issue: 3
ISSN: 0730-2312
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cell Biology
Non-NASA Center

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