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Hyaluronic acid is increased in the skin and urine in patients with amyotrophic lateral sclerosisWe performed morphological studies of skin and measured glycosaminoglycans in the urine from patients with sporadic amyotrophic lateral sclerosis (ALS) and control subjects. The wide spaces separating collagen bundles reacted strongly with alcian blue stain in ALS patients and stained more markedly as ALS progressed. Staining with alcian blue was virtually eliminated by Streptomyces hyaluronidase. The urinary excretion of hyaluronic acid (HA) (mg/day) was significantly increased (P < 0.01) in ALS patients compared with that of control subjects, and there was a significant positive correlation between the excreted amount of HA and the duration of illness in advanced ALS patients with a duration of more than 2 years from clinical onset (r = 0.72, P < 0.02). We suggest that sporadic ALS includes a metabolic disorder of HA in which an accumulation of HA in the skin is linked to an increased urinary excretion of HA.
Document ID
20040173121
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Ono, S.
(Teikyo University School of Medicine, Ichihara Hospital Chiba, Japan)
Imai, T.
Yamauchi, M.
Nagao, K.
Date Acquired
August 22, 2013
Publication Date
October 1, 1996
Publication Information
Publication: Journal of neurology
Volume: 243
Issue: 10
ISSN: 0340-5354
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: DE 10489
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Musculoskeletal
Non-NASA Center

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