NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Clinical models of cardiovascular regulation after weightlessnessAfter several days in microgravity, return to earth is attended by alterations in cardiovascular function. The mechanisms underlying these effects are inadequately understood. Three clinical disorders of autonomic function represent possible models of this abnormal cardiovascular function after spaceflight. They are pure autonomic failure, baroreflex failure, and orthostatic intolerance. In pure autonomic failure, virtually complete loss of sympathetic and parasympathetic function occurs along with profound and immediate orthostatic hypotension. In baroreflex failure, various degrees of debuffering of blood pressure occur. In acute and complete baroreflex failure, there is usually severe hypertension and tachycardia, while with less complete and more chronic baroreflex impairment, orthostatic abnormalities may be more apparent. In orthostatic intolerance, blood pressure fall is minor, but orthostatic symptoms are prominent and tachycardia frequently occurs. Only careful autonomic studies of human subjects in the microgravity environment will permit us to determine which of these models most closely reflects the pathophysiology brought on by a period of time in the microgravity environment.
Document ID
20040173134
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Robertson, D.
(Vanderbilt University Nashville, TN 37232-2195, United States)
Jacob, G.
Ertl, A.
Shannon, J.
Mosqueda-Garcia, R.
Robertson, R. M.
Biaggioni, I.
Date Acquired
August 22, 2013
Publication Date
October 1, 1996
Publication Information
Publication: Medicine and science in sports and exercise
Volume: 28
Issue: 10 Suppl
ISSN: 0195-9131
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: RR00095
CONTRACT_GRANT: HL46680
CONTRACT_GRANT: NS33460
Distribution Limits
Public
Copyright
Other
Keywords
Review, Tutorial
NASA Discipline Cardiopulmonary
NASA Discipline Number 08-10
NASA Program Space Physiology and Countermeasures
Non-NASA Center
Review

Available Downloads

There are no available downloads for this record.
No Preview Available