NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Mineralization of collagen may occur on fibril surfaces: evidence from conventional and high-voltage electron microscopy and three-dimensional imagingThe interaction between collagen and mineral crystals in the normally calcifying leg tendons from the domestic turkey, Meleagris gallopavo, has been investigated at an ultrastructural level with conventional and high-voltage electron microscopy, computed tomography, and three-dimensional image reconstruction methods. Specimens treated by either aqueous or anhydrous techniques and resin-embedded were appropriately sectioned and regions of early tendon mineralization were photographed. On the basis of individual photomicrographs, stereoscopic pairs of images, and tomographic three-dimensional image reconstructions, platelet-shaped crystals may be demonstrated for the first time in association with the surface of collagen fibrils. Mineral is also observed in closely parallel arrays within collagen hole and overlap zones. The mineral deposition at these spatially distinct locations in the tendon provides insight into possible means by which calcification is mediated by collagen as a fundamental event in skeletal and dental formation among vertebrates.
Document ID
20040173183
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Landis, W. J.
(Harvard Medical School Boston, Massachusetts, United States)
Hodgens, K. J.
Song, M. J.
Arena, J.
Kiyonaga, S.
Marko, M.
Owen, C.
McEwen, B. F.
Date Acquired
August 22, 2013
Publication Date
July 1, 1996
Publication Information
Publication: Journal of structural biology
Volume: 117
Issue: 1
ISSN: 1047-8477
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: AR 34081
CONTRACT_GRANT: AR 34078
CONTRACT_GRANT: AR 41452
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Musculoskeletal
NASA Discipline Number 40-40
Non-NASA Center
NASA Program Space Biology

Available Downloads

There are no available downloads for this record.
No Preview Available