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Cerebral cortical neurons with activity linked to central neurogenic spontaneous and evoked elevations in cerebral blood flowWe recorded neurons in rat cerebral cortex with activity relating to the neurogenic elevations in regional cerebral blood flow (rCBF) coupled to stereotyped bursts of EEG activity, burst-cerebrovascular wave complexes, appearing spontaneously or evoked by electrical stimulation of rostral ventrolateral medulla (RVL) or fastigial nucleus (FN). Of 333 spontaneously active neurons only 15 (5%), in layers 5-6, consistently (P < 0.05, chi-square) increased their activity during the earliest potential of the complex, approximately 1.3 s before the rise of rCBF, and during the minutes-long elevation of rCBF elicited by 10 s of stimulation of RVL or FN. The results indicate the presence of a small population of neurons in deep cortical laminae whose activity correlates with neurogenic elevations of rCBF. These neurons may function to transduce afferent neuronal signals into vasodilation.
Document ID
20040173216
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Golanov, E. V.
(Cornell University Medical College New York, NY 10021, United States)
Reis, D. J.
Date Acquired
August 22, 2013
Publication Date
May 10, 1996
Publication Information
Publication: Neuroscience letters
Volume: 209
Issue: 2
ISSN: 0304-3940
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cardiopulmonary
Non-NASA Center

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