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What is the minimal vestibular function required for compensation?Living with an uncompensated, abnormal vestibular system requires oppressive modification of life style and often prevents return to work and activities of daily living. Patients with vestibular abnormalities were studied to determine the minimal residual vestibular function required to achieve compensation. Three groups of patients with (a) complete unilateral loss of vestibular function with normal horizontal canal-vestibulo-ocular (HCVOR) function in the opposite ear, (b) complete unilateral loss with abnormal HCVOR function in the opposite ear, and (c) bilateral reduction of vestibular function from aminoglycoside toxicity underwent vestibuloocular (VOR), optokinetic (OKN), visual-VOR (VVOR), and computerized dynamic posturography (CDP) tests before and after therapeutic procedures. Results suggest that a minimal VOR response amplitude must be present for compensation of VVOR function to occur. The roles of VOR and OKN phase shifts in vestibular compensation are more complicated and require further study. Compensation of vestibulospinal function does not necessarily accompany VOR or VVOR compensation. Ascending and descending vestibular compensatory mechanisms may involve different spatial sensory inputs. Results of these studies have important implications for the diagnosis and treatment of patients with vestibular disorders, including selection and monitoring of patients for therapeutic regimens such as vestibular nerve section and streptomycin therapy.
Document ID
20040173222
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Black, F. O.
Wade, S. W.
Nashner, L. M.
Date Acquired
August 22, 2013
Publication Date
May 1, 1996
Publication Information
Publication: The American journal of otology
Volume: 17
Issue: 3
ISSN: 0192-9763
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: R01 DC00205
CONTRACT_GRANT: R01 NS 19221
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Neuroscience

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