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Short-term space flight on nitrogenous compounds, lipoproteins, and serum proteinsBiochemical variables in blood were measured in venous blood samples from 38 to 72 Space Shuttle astronauts before and immediately after flights of 2 to 11 days. Mean pre- and postflight values were compared using the paired t-test or the Wilcoxon signed-rank test. The largest change in serum enzymes was a 21% increase (P = .0014) in gamma-glutamyl-transpeptidase, which may have been related to stress. The median value of apolipoprotein (apo) A-I decreased from 152 to 127 mg/dL (P < .0001), but the change in apo B (77 to 73 mg/dL) was not statistically significant, and the mean apo A-I/apo B ratio remained well above 1.5. A decrease in dietary fat and cholesterol intake during shuttle missions may have been a cause of the change in apo A-I. Twelve of the 16 nonenzyme serum proteins measured were significantly elevated (P < .05), possibly because of hemoconcentration and increased protein catabolism. The 56% increase in haptoglobin may be related to release of suppressed erythropoiesis at landing.
Document ID
20040193146
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Leach, C. S.
(NASA Johnson Space Center Houston, TX United States)
Lane, H. W.
Krauhs, J. M.
Date Acquired
August 22, 2013
Publication Date
May 1, 1994
Publication Information
Publication: Journal of clinical pharmacology
Volume: 34
Issue: 5
ISSN: 0091-2700
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other

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