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Effects of angiotensin, vasopressin and atrial natriuretic peptide on intraocular pressure in anesthetized ratsThe effects of atrial natriuretic peptide (ANP), vasopressin (AVP) and angiotensin (ANG) on blood and intraocular pressures of pentobarbital anesthetized rats were evaluated following intravenous, intracerebroventricular or anterior chamber routes of administration. Central injections did not affect intraocular pressure. Equipressor intravenous infusions of ANG raised, whereas AVP decreased, intraocular pressure. Direct infusions of a balanced salt solution (0.175 microliter/min) raised intraocular pressure between 30 and 60 min. Adding ANG or ANP slightly reduced this solvent effect but AVP was markedly inhibitory. An AVP-V1 receptor antagonist reversed the blunting of the solvent-induced rise by the peptide, indicating receptor specificity. Acetazolamide pretreatment lowered intraocular pressure, but the solvent-induced rise in intraocular pressure and inhibition by AVP still occurred without altering the temporal pattern. Thus, these effects appear unrelated to aqueous humor synthesis rate. The data support the possibility of intraocular pressure regulation by peptides acting from the blood and aqueous humor.
Document ID
20050000130
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Palm, D. E.
(College of Medicine, Pennsylvania State University Hershey 17033, United States)
Shue, S. G.
Keil, L. C.
Balaban, C. D.
Severs, W. B.
Date Acquired
August 22, 2013
Publication Date
October 1, 1995
Publication Information
Publication: Neuropeptides
Volume: 29
Issue: 4
ISSN: 0143-4179
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Number 14-10
NASA Discipline Cardiopulmonary
NASA Center ARC
NASA Program Space Physiology and Countermeasures

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