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The effect of space and parabolic flight on macrophage hematopoiesis and functionWe used weak electric fields to monitor macrophage spreading in microgravity. Using this technique, we demonstrated that bone marrow-derived macrophages responded to microgravity within 8 s. We also showed that microgravity differentially altered two processes associated with bone marrow-derived macrophage development. Spaceflight enhanced cellular proliferation and inhibited differentiation. These data indicate that the space/microgravity environment significantly affects macrophages.
Document ID
20050000265
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Armstrong, J. W.
(Kansas State University Manhattan 66506-4901)
Gerren, R. A.
Chapes, S. K.
Spooner, B. S.
Date Acquired
August 22, 2013
Publication Date
January 1, 1995
Publication Information
Publication: Experimental cell research
Volume: 216
Issue: 1
ISSN: 0014-4827
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cell Biology
STS-57 Shuttle Project
short duration
STS-62 Shuttle Project
Parabolic Flight
STS-60 Shuttle Project
Non-NASA Center
manned
Flight Experiment

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