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Contribution of dietary and loading changes to the effects of suspension on mouse femoraThe present study assessed the contributions of feeding changes and unloading to the overall measured effects of 2-wk hindlimb (Tail) suspension on the mouse femora. Feeding changes were addressed by considering the effects of matched feeding among suspended and control mice. The effects of hind limb unloading were considered by comparing suspended mice to mice equipped identically (though not suspended) and matched-fed. The feeding and unloading aspects of suspension appear to cause distinctly differing effects on the stereotypic modeling of the femora. Matched-feeding was accompanied by increased resorption surface in comparison to suspended mice, while unloading led to reduced bone formation at the mid-diaphysis of the femora. Reduced mineral content was observed in the bones of suspended mice when compared to the other mice groups, but without increased resorption surface. Thus, the unloading aspects of the antiorthostatic suspension protocol apparently causes reduced formation and mineralization in the femur.
Document ID
20050000328
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Simske, S. J.
(University of Colorado Boulder 80309)
Broz, J. J.
Fleet, M. L.
Schmeister, T. A.
Gayles, E. C.
Luttges, M. W.
Spooner, B. S.
Date Acquired
August 22, 2013
Publication Date
July 1, 1994
Publication Information
Publication: The Journal of experimental zoology
Volume: 269
Issue: 3
ISSN: 0022-104X
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Developmental Biology

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