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Negative regulators of cell proliferationCell proliferation is governed by the influence of both mitogens and inhibitors. Although cell contact has long been thought to play a fundamental role in cell cycling regulation, and negative regulators have long been suspected to exist, their isolation and purification has been complicated by a variety of technical difficulties. Nevertheless, over recent years an ever-expanding list of putative negative regulators have emerged. In many cases, their biological inhibitory activities are consistent with density-dependent growth inhibition. Most likely their interactions with mitogenic agents, at an intracellular level, are responsible for either mitotic arrest or continued cell cycling. A review of naturally occurring cell growth inhibitors is presented with an emphasis on those factors shown to be residents of the cell surface membrane. Particular attention is focused on a cell surface sialoglycopeptide, isolated from intact bovine cerebral cortex cells, which has been shown to inhibit the proliferation of an unusually wide range of target cells. The glycopeptide arrest cells obtained from diverse species, both fibroblasts and epithelial cells, and a broad variety of transformed cells. Signal transduction events and a limited spectrum of cells that are refractory to the sialoglycopeptide have provided insight into the molecular events mediated by this cell surface inhibitor.
Document ID
20050000369
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Johnson, T. C.
(Kansas State University Manhattan 66506)
Spooner, B. S.
Date Acquired
August 22, 2013
Publication Date
April 1, 1994
Publication Information
Publication: Pharmacology & therapeutics
Volume: 62
Issue: 1-2
ISSN: 0163-7258
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Review
Review, Tutorial
NASA Discipline Cell Biology
Non-NASA Center

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