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Influence of antiorthostatic suspension on resistance to murine Listeria monocytogenes infectionThe present study was designed to evaluate the influence of antiorthostatic suspension, a ground-based modeling system employed to simulate certain aspects of weightlessness that occur during space flight, on the capacity of mice to resist infection with the facultative intracellular bacterial pathogen Listeria monocytogenes. Female BDF1 mice were suspended by the tail in the orthostatic or antiorthostatic position and were infected with a sublethal dose of virulent L. monocytogenes at various times during the suspension. It was found that suspension did not influence the kinetics of bacterial growth in vivo if the infection was started concurrently with the suspension. However, mice that were antiorthostatically suspended 2, 4, or 7 days before the onset of infection exhibited an enhanced capacity to eliminate the challenge infection. Suspending mice on day 2 of the infection did not alter the kinetics of bacterial growth. Finally, the enhancement of resistance to the primary Listeria infection was accompanied by failure of the mice to generate long-term protective immunological memory to the challenge organism. Collectively, these results indicate that the stress of antiorthostatic suspension can influence the capacity of mice to resist bacterial infection.
Document ID
20050000378
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Miller, E. S.
(School of Medicine, University of Louisville)
Sonnenfeld, G.
Date Acquired
August 22, 2013
Publication Date
March 1, 1994
Publication Information
Publication: Journal of leukocyte biology
Volume: 55
Issue: 3
ISSN: 0741-5400
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Regulatory Physiology
Non-NASA Center

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