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Overview of spaceflight immunology studiesThe effects of spaceflight and analogues of spaceflight are discussed here and in nine accompanying articles. In this summary we present spaceflight studies with human subjects, animal subjects, and cell cultures and we review ground-based systems used to model the observed effects of spaceflight on the immune system. Human paradigms include bed rest, academic or psychological stress, physical stress, hypobaric or high altitude stress, and confinement. Animal models include antiorthostatic and orthostatic suspension, hypobarism, and confinement. The ten manuscripts in this collection were selected to provide a summary that should give the reader an overview of the various activities of spaceflight immunology researchers throughout the history of space travel. This manuscript identifies the major contributors to the study of spaceflight immunology, explains what types of studies have been conducted, and how they have changed over the years. Also presented is a discussion of the unusual limitations associated with spaceflight research and the efforts to develop appropriate ground-based surrogate model systems. Specific details, data, and mechanistic speculations will be held to a minimum, because they will be discussed in depth in the other articles in the collection.
Document ID
20050000430
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Taylor, G. R.
(NASA Johnson Space Center Houston, TX United States)
Date Acquired
August 22, 2013
Publication Date
September 1, 1993
Publication Information
Publication: Journal of leukocyte biology
Volume: 54
Issue: 3
ISSN: 0741-5400
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Number 18-10
manned
Review
NASA Discipline Regulatory Physiology
Apollo Project
NASA Center JSC
NASA Program Space Physiology and Countermeasures
Review, Tutorial
Salyut Project
short duration
Flight Experiment
Mir Project
long duration
STS Shuttle Project

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