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[Genotoxic modification of nucleic acid bases and biological consequences of it. Review and prospects of experimental and computational investigations]The review is presented of experimental and computational data on the influence of genotoxic modification of bases (deamination, alkylation, oxidation) on the structure and biological functioning of nucleic acids. Pathways are discussed for the influence of modification on coding properties of bases, on possible errors of nucleic acid biosynthesis, and on configurations of nucleotide mispairs. The atomic structure of nucleic acid fragments with modified bases and the role of base damages in mutagenesis and carcinogenesis are considered.
Document ID
20050000447
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Poltev, V. I.
Bruskov, V. I.
Shuliupina, N. V.
Rein, R.
Shibata, M.
Ornstein, R.
Miller, J.
Date Acquired
August 22, 2013
Publication Date
July 1, 1993
Publication Information
Publication: Molekuliarnaia biologiia
Volume: 27
Issue: 4
ISSN: 0026-8984
Subject Category
Exobiology
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
Review, Academic
NASA Discipline Exobiology
Review

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