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Cell proliferation and differentiation in chemical leukemogenesisIn tissues such as bone marrow with normally high rates of cell division, proliferation is tightly coordinated with cell differentiation. Survival, proliferation and differentiation of early hematopoietic progenitor cells depend on the growth factors, interleukin 3 (IL-3) and/or granulocyte-macrophage colony stimulating factor (GM-CSF) and their synergism with other cytokines. We provide evidence that a characteristic shared by a diverse group of compounds with demonstrated leukemogenic potential is the ability to act synergistically with GM-CSF. This results in an increase in recruitment of a resting population of hematopoietic progenitor cells normally unresponsive to the cytokine and a twofold increase in the size of the proliferating cell population normally regarded to be at risk of transformation in leukemogenesis. These findings support the possibility that transient alterations in hematopoietic progenitor cell differentiation may be an important factor in the early stages of development of leukemia secondary to chemical or drug exposure.
Document ID
20050000481
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Irons, R. D.
(School of Pharmacy, University of Colorado Health Sciences Center Denver 80262)
Stillman, W. S.
Clarkson, T. W.
Date Acquired
August 22, 2013
Publication Date
May 1, 1993
Publication Information
Publication: Stem cells (Dayton, Ohio)
Volume: 11
Issue: 3
ISSN: 1066-5099
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Environmental Health

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