NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Elevated 1,25-dihydroxyvitamin D levels in patients with chronic obstructive pulmonary disease treated with prednisoneGlucocorticoid administration is a well established cause of osteopenia. Mechanisms underlying the deleterious effect of glucocorticoids on bone may include direct inhibition of bone formation as well as indirect effects through changes in intestinal calcium absorption, renal calcium excretion, and/or levels of the calciotropic hormones. To further examine the potential role of the calciotropic hormones we measured serum levels of PTH and 1,25 dihydroxyvitamin D [1,25(OH)2D], as well as serum and urine levels of calcium and vertebral bone density in patients with chronic obstructive pulmonary disease being managed with or without prednisone. Patients treated with prednisone had lower spinal bone density (53 vs. 106 mg/cm3) and higher serum calcium (2.40 vs. 2.33 mmol/l), urine calcium (6.9 vs. 2.7 mmol/24h), and 1,25(OH)2D levels (147 vs. 95 pmol/L). Compared to the patients not treated with glucocorticoids. PTH levels also tended to be higher (33 vs. 26 microliters-eq/ml), but the difference was not significant. Serum and urine calcium levels correlated positively with 1,25(OH)2D levels, but none of these measurements correlated with PTH levels. Our results suggest that prednisone treatment alters the regulation of 1,25(OH)2D production, and this may contribute to the loss of bone mineral induced by prednisone.
Document ID
20050000520
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Bikle, D. D.
(VA Medical Center San Francisco, California)
Halloran, B.
Fong, L.
Steinbach, L.
Shellito, J.
Date Acquired
August 22, 2013
Publication Date
February 1, 1993
Publication Information
Publication: The Journal of clinical endocrinology and metabolism
Volume: 76
Issue: 2
ISSN: 0021-972X
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: DK-33964
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Number 40-40
NASA Discipline Number 00-00
NASA Program Space Biology
NASA Program Flight
Non-NASA Center
NASA Discipline Musculoskeletal

Available Downloads

There are no available downloads for this record.
No Preview Available