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Space flight and the immune systemDepression of lymphocyte response to mitogens in cosmonauts after space flight was reported for the first time in the early 1970s by Soviet immunologists. Today we know that depression of lymphocyte function affects at least 50% of space crew members. Investigations on the ground on subjects undergoing physical and psychological stress indicate that stress is a major factor in immune depression of astronauts. This is despite the fact that weightlessness per se has a strong inhibitory effect on lymphocyte activation in vitro. Although the changes observed never harmed the health of astronauts, immunological changes must be seriously investigated and understood in view of long-duration flight on space stations in an Earth orbit, to other planets such as Mars and to the Moon.
Document ID
20050000525
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Cogoli, A.
(Space Biology Group Institute of Biotechnology, ETH Honggerberg Zurich, Switzerland)
Date Acquired
August 22, 2013
Publication Date
January 1, 1993
Publication Information
Publication: Vaccine
Volume: 11
Issue: 5
ISSN: 0264-410X
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Regulatory Physiology
Skylab Project
Flight Experiment
Cosmos Project
NASA Program Flight
long duration
Salyut Project
unmanned
short duration
STS Shuttle Project
manned
NASA Discipline Number 00-00
Non-NASA Center
Apollo Project

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