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Glutamate and aspartate are decreased in the skin in amyotrophic lateral sclerosisWe measured the levels of amino acids in biopsied skin from eight patients with amyotrophic lateral sclerosis (ALS) and seven controls. The most conspicuous changes in ALS patients were as follows. First, the contents of the acidic amino acids glutamate and aspartate were significantly decreased in ALS, and were negatively and significantly associated with the duration of illness. Second, the levels of the collagen-associated amino acids hydroxyproline, proline, glycine, alanine, and hydroxylysine were significantly decreased in ALS, and correlated inversely with the duration of illness. These results suggest that there are abnormalities of acidic amino acids and collagen-associated amino acids in the skin of patients with ALS. These changes may underlie the pathogenesis of ALS.
Document ID
20050000584
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Ono, S.
(Dental Research Center, University of North Carolina Chapel Hill 27599-7455)
Yamauchi, M.
Date Acquired
August 22, 2013
Publication Date
November 1, 1992
Publication Information
Publication: Acta neurologica Scandinavica
Volume: 86
Issue: 5
ISSN: 0001-6314
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: DE 11233
CONTRACT_GRANT: DE 18522
CONTRACT_GRANT: DE 08611
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Musculoskeletal
Non-NASA Center

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