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Recovery of vestibular function following hair cell destruction by streptomycinCan the vestibular periphery of warm-blooded vertebrates recover functionally from severe sensory hair cell loss? Recent findings in birds suggest a mechanism for recovery but in fact no direct functional evidence has been reported. We produced vestibular hair cell lesions using the ototoxic agent streptomycin sulfate (600 mg/kg/day, 8 days, chicks, Gallus domesticus). Compound action potentials of the vestibular nerve were used as a direct measure of peripheral vestibular function. Vestibular thresholds, neural activation latencies and amplitudes were documented. Eight days of drug treatment elevated thresholds significantly (P < 0.001) and eliminated all but remnants of vestibular activity. Virtually complete physiological recovery occurred in all animals studied over a period of 70 days following treatment. Thresholds recovered within two weeks of drug treatment whereas the return of response morphologies including activation latencies and amplitudes required an additional 6-8 weeks.
Document ID
20050000600
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Jones, T. A.
(University of Nebraska Medical Center, College of Dentistry Lincoln 68583-0740)
Nelson, R. C.
Date Acquired
August 22, 2013
Publication Date
October 1, 1992
Publication Information
Publication: Hearing research
Volume: 62
Issue: 2
ISSN: 0378-5955
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Neuroscience

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