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Amyotrophic lateral sclerosis: increased solubility of skin collagenWe studied the solubility of skin collagen from six patients with amyotrophic lateral sclerosis (ALS) and six controls. The amount of collagen extracted with neutral salt solution was significantly greater in patients with ALS than in controls. In addition, there was a statistically significant increase in the proportion of collagen extracted from ALS patients with increased duration of illness. The collagen solubilized by pepsin and cyanogen bromide treatments was significantly higher in ALS patients than in controls, and its proportion was positively and significantly associated with duration of illness in ALS patients. These results indicate that the metabolism of skin collagen may be affected in the disease process of ALS, causing an increase in immature soluble collagen in the tissue, which is the opposite to that which occurs in the normal aging process.
Document ID
20050000625
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Ono, S.
(Dental Research Center, University of North Carolina Chapel Hill 27599-7455)
Yamauchi, M.
Date Acquired
August 22, 2013
Publication Date
August 1, 1992
Publication Information
Publication: Neurology
Volume: 42
Issue: 8
ISSN: 0028-3878
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: DE 08611
CONTRACT_GRANT: DE 08522
CONTRACT_GRANT: DE 00233
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Musculoskeletal
Non-NASA Center

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