NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Effect of total parenteral nutrition, systemic sepsis, and glutamine on gut mucosa in ratsThe effect of the combination of total parenteral nutrition (TPN) and systemic sepsis on mucosal morphology and protein synthesis was investigated. Rats were given a standard TPN mixture consisting of glucose (216 kcal.kg-1.day-1), lipid (24 kcal.kg-1.day-1), and amino acids (1.5 g N.kg-1.day-1) for 5 days. On the 5th day the rats (n = 37) were randomized into four groups according to diet as follows: 1) control nonseptic on standard TPN, 2) control nonseptic on TPN with glutamine, 3) septic on standard TPN, and 4) septic with the TPN supplemented with glutamine. Twenty hours after the injection of Escherichia coli, the rats were given a 4-h constant infusion of [U-14C]leucine to determine the mucosal fractional protein synthesis rates. The following results were obtained. 1) Histological examination showed that systemic sepsis caused tissue damage to the ileum and jejunum. 2) Glutamine supplementation attenuated these changes. 3) There were no visible changes to the colon either from glutamine supplementation or sepsis. 4) Sepsis was associated with an increase in mucosal protein synthesis and decreased muscle synthesis. 5) Addition of glutamine to the TPN mix further increased protein synthesis in the intestinal mucosa of septic rats.
Document ID
20050000628
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Yoshida, S.
(University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine Camden 08103)
Leskiw, M. J.
Schluter, M. D.
Bush, K. T.
Nagele, R. G.
Lanza-Jacoby, S.
Stein, T. P.
Date Acquired
August 22, 2013
Publication Date
August 1, 1992
Publication Information
Publication: The American journal of physiology
Volume: 263
Issue: 2 Pt 1
ISSN: 0002-9513
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: DK-35612
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal

Available Downloads

There are no available downloads for this record.
No Preview Available