NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Modeling the effects of hypoxia on ATP turnover in exercising muscleMost models of metabolic control concentrate on the regulation of ATP production and largely ignore the regulation of ATP demand. We describe a model, based on the results of Hogan et al. (J. Appl. Physiol. 73: 728-736, 1992), that incorporates the effects of ATP demand. The model is developed from the premise that a unique set of intracellular conditions can be measured at each level of ATP turnover and that this relationship is best described by energetic state. Current concepts suggest that cells are capable of maintaining oxygen consumption in the face of declines in the concentration of oxygen through compensatory changes in cellular metabolites. We show that these compensatory changes can cause significant declines in ATP demand and result in a decline in oxygen consumption and ATP turnover. Furthermore we find that hypoxia does not directly affect the rate of anaerobic ATP synthesis and associated lactate production. Rather, lactate production appears to be related to energetic state, whatever the PO2. The model is used to describe the interaction between ATP demand and ATP supply in determining final ATP turnover.
Document ID
20050000636
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Arthur, P. G.
(University of British Columbia Vancouver, Canada)
Hogan, M. C.
Bebout, D. E.
Wagner, P. D.
Hochachka, P. W.
Date Acquired
August 22, 2013
Publication Date
August 1, 1992
Publication Information
Publication: Journal of applied physiology (Bethesda, Md. : 1985)
Volume: 73
Issue: 2
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: HL-17731
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal

Available Downloads

There are no available downloads for this record.
No Preview Available