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The effect of in situ freezing on rabbit patellar tendon. A histologic, biochemical, and biomechanical analysisCell necrosis has been well documented as one of the many changes that occur in autogenous tendon when it is used to reconstruct the anterior cruciate ligament. The purpose of this experiment was to isolate cell necrosis as a variable and study its effect on the patellar tendon. To accomplish this, both knees of 25 New Zealand White rabbits were operated on. In one knee, a 5-mm wide band of patellar tendon was subjected to two rapid freeze-thaw cycles, while the other knee underwent sham surgery. Histologic evaluation showed a zone of necrosis at 2 and 4 weeks with cellular repopulation complete at 8 weeks. patellar tendon cross-sectional area was 0.118 cm2 at 8 weeks for the frozen specimens compared to 0.102 cm2 for the sham-operated controls. This difference was significant at the P = 0.025 level. Mechanical testing at 4 and 8 weeks revealed no significant changes in tendon length, maximum load, or stiffness. The collagen content was also unchanged at both 4 and 8 weeks.
Document ID
20050000642
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Graf, B. K.
(University of Wisconsin Madison)
Fujisaki, K.
Vanderby, R. Jr
Vailas, A. C.
Date Acquired
August 22, 2013
Publication Date
July 1, 1992
Publication Information
Publication: The American journal of sports medicine
Volume: 20
Issue: 4
ISSN: 0363-5465
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal

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