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Metabotropic glutamate receptors are required for the induction of long-term potentiationRecent observations have led to the suggestion that the metabotropic glutamate receptor may play a role in the induction or maintenance of long-term potentiation (LTP). However, experimental evidence supporting a role for this receptor in the induction of LTP is still inconclusive and controversial. Here we report that, in rat dorsolateral septal nucleus (DLSN) neurons, which have the highest density of metabotropic receptors and show functional responses, the induction of LTP is not blocked by the NMDA receptor antagonist 2-amino-5-phosphonovalerate, but is blocked by two putative metabotropic glutamate receptor antagonists, L-2-amino-3-phosphonopropionic acid and L-2-amino-4-phosphonobutyrate. Furthermore, superfusion of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid, a selective metabotropic glutamate agonist, resulted in a long-lasting potentiation of synaptic transmission similar to that induced by tetanic stimuli. Our results demonstrated that activation of postsynaptic metabotropic receptors is both necessary and sufficient for the induction of LTP in the DLSN, and we suggest that such a mechanism may be important at other CNS synapses.
Document ID
20050000660
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Zheng, F.
(University of Texas Medical Branch Galveston 77550)
Gallagher, J. P.
Date Acquired
August 22, 2013
Publication Date
July 1, 1992
Publication Information
Publication: Neuron
Volume: 9
Issue: 1
ISSN: 0896-6273
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: MH39163
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Neuroscience

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