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Gastrointestinal citrate absorption in nephrolithiasisGastrointestinal absorption of citrate was measured in stone patients with idiopathic hypocitraturia to determine if citrate malabsorption could account for low urinary citrate. Citrate absorption was measured directly from recovery of orally administered potassium citrate (40 mEq.) in the intestinal lavage fluid, using an intestinal washout technique. In 7 stone patients citrate absorption, serum citrate levels, peak citrate concentration in serum and area under the curve were not significantly different from those of 7 normal subjects. Citrate absorption was rapid and efficient in both groups, with 96 to 98% absorbed within 3 hours. The absorption of citrate was less efficient from a tablet preparation of potassium citrate than from a liquid preparation, probably due to a delayed release of citrate from wax matrix. However, citrate absorption from solid potassium citrate was still high at 91%, compared to 98% for a liquid preparation. Thus, hypocitraturia is unlikely to be due to an impaired gastrointestinal absorption of citrate in stone patients without overt bowel disease.
Document ID
20050000719
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Fegan, J.
(University of Texas Southewestern Medical Center Dallas 75235-8885)
Khan, R.
Poindexter, J.
Pak, C. Y.
Date Acquired
August 22, 2013
Publication Date
May 1, 1992
Publication Information
Publication: The Journal of urology
Volume: 147
Issue: 5
ISSN: 0022-5347
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: P01-DK20543
CONTRACT_GRANT: 5T32-DK07307
CONTRACT_GRANT: M01-RR00633
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Regulatory Physiology

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