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Collagen cross-linking in sun-exposed and unexposed sites of aged human skinA recently described nonreducible, acid-heat stable compound, histidinohydroxylysinonorleucine (HHL), is a collagen cross-link isolated from mature skin tissue. Its abundance is related to chronologic aging of skin. The present communication describes the quantity of HHL from aged human skin of the same individuals in sun-exposed (wrist) and unexposed (buttock) sites. Punch biopsies were obtained from these sites from nine people of age 60 or older. HHL contents (moles/mole of collagen) at these sites were for wrist 0.13 +/- 0.07 and for buttock 0.69 +/- 0.17 (mean +/- SD, p less than 0.001). In addition, it was found that acute irradiation of the cross-linked peptides with UVA (up to 250 J/cm2) and UVB (up to 1 J/cm2) had no effect on HHL structure. The same treatment significantly degraded another nonreducible, stable collagen cross-link, pyridinoline. The results suggest that chronic sunlight exposure may be associated with an impediment to normal maturation of human dermal collagen resulting in tenuous amount of HHL. Thus, the process of photoaging in dermal collagen is different from that of chronologic aging in human skin.
Document ID
20050000837
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Yamauchi, M.
(Dental Research Center, University of North Carolina Chapel Hill 27599-7455)
Prisayanh, P.
Haque, Z.
Woodley, D. T.
Date Acquired
August 22, 2013
Publication Date
November 1, 1991
Publication Information
Publication: The Journal of investigative dermatology
Volume: 97
Issue: 5
ISSN: 0022-202X
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: DE00233
CONTRACT_GRANT: DE08522
CONTRACT_GRANT: DE08611
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal

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