NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Serotonin, atherosclerosis, and collateral vessel spasmStudies on animal models demonstrate that platelet products contribute to vascular spasm in ischemic syndromes and that this is reversible with administration of ketanserin and thromboxane synthesis inhibitors. Laboratory animals (dogs, rabbits, and rats) that had femoral artery ligations exhibited supersensitivity to serotonin within days in their collateral blood vessels. This supersensitivity lasted at least 6 months. The response to serotonin was reversed by ketanserin, but not by 5HT-1 antagonists. Supersensitivity does not extend to norepinephrine, and alpha blockers do not influence the response to serotonin. It appears that platelet activation by endothelial injury contributes to ischemia through blood vessel occlusion and vascular spasm. When platelet activation occurs in vivo, blood vessel occlusion and vascular spasm are reversible in part by using ketanserin or agents that block thromboxane synthesis or its action. Combining both classes of agents reverses spasm completely. These findings support existing evidence that platelet products contribute to vascular disease, and provide an approach to improved management with currently available pharmacologic agents.
Document ID
20050000918
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hollenberg, N.
(Brigham and Women's Hospital)
Date Acquired
August 22, 2013
Publication Date
July 1, 1988
Publication Information
Publication: American journal of hypertension : journal of the American Society of Hypertension
Volume: 1
Issue: 3 Pt 3
ISSN: 0895-7061
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Review, Tutorial
Review
Non-NASA Center
NASA Discipline Regulatory Physiology

Available Downloads

There are no available downloads for this record.
No Preview Available