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Inhibited interferon production after space flightSeveral studies have been performed in our laboratories indicating that interferon production may be impaired in rodents after space flight. Using an antiorthostatic suspension model that simulates some of the effects of microgravity seen during space flight, we have shown that interferon-alpha/beta production was inhibited. The inhibition was not due solely to the stress of suspension. The inhibited interferon production was transient, as suspended animals returned to normal caging recovered the ability to produce interferon. Antiorthostatic suspension of mice also resulted in a loss of resistance to infection with the diabetogenic strain of encephalomyocarditis virus, which correlated with the drop in interferon production. In rats flown in US Space Shuttle mission SL-3, interferon-gamma production was inhibited severely when spleen cells were challenged with concanavalin-A upon return to earth. In contrast, interleukin-3 production by these cells was normal. These results suggest that immune responses may be altered after antiorthostatic modeling or space flight, and the resistance to viral infections may be especially affected.
Document ID
20050000927
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Sonnenfeld, G.
(University of Louisville School of Medicine and Dentistry Kentucky)
Gould, C. L.
Williams, J.
Mandel, A. D.
Date Acquired
August 22, 2013
Publication Date
January 1, 1988
Publication Information
Publication: Acta microbiologica Hungarica
Volume: 35
Issue: 4
ISSN: 0231-4622
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Flight Experiment
Non-NASA Center
STS-51B Shuttle Project
NASA Discipline Regulatory Physiology
manned
short duration
NASA Center ARC

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