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Immune changes during short-duration missionsSpaceflight materially influences the immune mechanism of humans and animals. Effects resulting from missions of less than 1 month are examined. Effects from longer missions are discussed in the companion paper by Konstantinova et al. Most immunology studies have involved analyses of subjects and samples from subjects obtained after flight, with the data being compared with similar data obtained before flight. These studies have demonstrated that short-duration missions can result in a postflight depression in blast cell transformation, major changes in cytokine function, and alterations in the relative numbers of immune cell populations. In addition to these post- vs. preflight studies, some data have been produced in flight. However, these in vitro analyses have been less than satisfactory because of differences between in-flight and ground-control conditions. Recently, both the U.S. and Russian space programs have started collecting in-flight, in vivo, cell-mediated immunity data. These studies have confirmed that the human cell-mediated immune system is blunted during spaceflight.
Document ID
20050009838
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Taylor, G. R.
(NASA Johnson Space Center Houston, TX United States)
Date Acquired
August 22, 2013
Publication Date
September 1, 1993
Publication Information
Publication: Journal of leukocyte biology
Volume: 54
Issue: 3
ISSN: 0741-5400
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
Skylab Project
NASA Program Space Physiology and Countermeasures
NASA Experiment Number AR-002
Flight Experiment
STS Shuttle Project
NASA Discipline Number 18-10
Salyut Project
NASA Experiment Number AP002
Soyuz Project
Apollo-Soyuz Project
long duration
NASA Discipline Regulatory Physiology
NASA Center JSC
Apollo Project

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