NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Zinc, copper, and nitrogen balances during bed rest and fluoride supplementation in healthy adult malesThe effects of bed rest and fluoride supplementation on zinc, copper, and nitrogen balances and Zn and Cu serum levels were measured in 15 healthy males. Subjects aged 19-54 y remained on a metabolic research ward for 10 wk. During weeks 1-5, subjects were ambulatory. During wks 6-10 they remained in continuous bed rest. During weeks 3-10 nine subjects received 10 or 20 mg F/d as sodium fluoride. Daily urine and weekly fecal composites were made and biweekly fasting blood samples were taken. Dietary intakes were 1.40 +/- 0.17 mg Cu/d (22.0 +/- 2.7 mumol Cu/d), 10.82 +/- 0.49 mg Zn/d (165.6 +/- 7.6 mumol Zn/d), and 14.27 +/- 0.23 g N/d (1019 +/- 16 mmol N/d). Bed rest increased urinary Zn and N excretions and fecal Zn excretions and decreased Zn balance (p less than 0.05) whereas Cu balance was unchanged. During bed rest, F supplementation increased Zn and N balances compared with untreated control subjects (p less than 0.05). These results are compatible with bone and muscle atrophy during bed rest and increased bone formation with F supplementation.
Document ID
20050037260
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Krebs, J. M.
(NASA Johnson Space Center Houston, TX United States)
Schneider, V. S.
LeBlanc, A. D.
Date Acquired
August 22, 2013
Publication Date
March 1, 1988
Publication Information
Publication: The American journal of clinical nutrition
Volume: 47
Issue: 3
ISSN: 0002-9165
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: RR02558
CONTRACT_GRANT: RR00350
Distribution Limits
Public
Copyright
Other
Keywords
Clinical Trial
Controlled Clinical Trial

Available Downloads

There are no available downloads for this record.
No Preview Available