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Simultaneous measurement of multiple radiation-induced protein expression profiles using the Luminex(TM) systemSpace flight results in the exposure of astronauts to a mixed field of radiation composed of energetic particles of varying energies, and biological indicators of space radiation exposure provides a better understanding of the associated long-term health risks. Current methods of biodosimetry have employed the use of cytogenetic analysis for biodosimetry, and more recently the advent of technological progression has led to advanced research in the use of genomic and proteomic expression profiling to simultaneously assess biomarkers of radiation exposure. We describe here the technical advantages of the Luminex(TM) 100 system relative to traditional methods and its potential as a tool to simultaneously profile multiple proteins induced by ionizing radiation. The development of such a bioassay would provide more relevant post-translational dynamics of stress response and will impart important implications in the advancement of space and other radiation contact monitoring. c2004 COSPAR. Published by Elsevier Ltd. All rights reserved.
Document ID
20050193746
Acquisition Source
Johnson Space Center
Document Type
Reprint (Version printed in journal)
Authors
Desai, N.
(Wyle Laboratories Houston, TX 77058, United States)
Wu, H.
George, K.
Gonda, S. R.
Cucinotta, F. A.
Cucniotta, F. A.
Date Acquired
August 23, 2013
Publication Date
January 1, 2004
Publication Information
Publication: Advances in space research : the official journal of the Committee on Space Research (COSPAR)
Volume: 34
Issue: 6
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Center JSC
NASA Discipline Radiation Health

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