NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Microgravity and Cellular Consequences in Lymphocyte FunctionMammalian cells adapt to the environment of low gravity and express a series of responses, some possibly from direct effects on cells and others based on environmental conditions created by microgravity. Human lymphocytes in microgravity culture are functionally diminished in activation and locomotion. Both processes are integral to optimal immune response to fight pathogens. The NASA Rotating-wall vessel (RWV) is a well-accepted analog for microgravity culture on the ground. Gene array experiments and immunoblotting identified upstream events in human lymphocytes adapting to microgravity analog culture. Microgravity induces selective changes, many of which are cell membrane related. Results showed that upstream of PKC in the T cell activation cascade, PLC-gamma and LAT are significantly diminished. ZAP 70 which controls LAT activation is also down regulated in modeled microgravity. Thus events governing cell shape might warrant attention in microgravity conditions. The goal of this study is to delineate response suites that are consequential, direct or indirect effects of the microgravity environment and which of these are essential to lymphocytes
Document ID
20050217302
Acquisition Source
Johnson Space Center
Document Type
Preprint (Draft being sent to journal)
Authors
Pellis, Neal R.
(NASA Johnson Space Center Houston, TX, United States)
Sundaresan, Alamelu
(Universities Space Research Association Houston, TX, United States)
Date Acquired
August 23, 2013
Publication Date
January 1, 2004
Subject Category
Life Sciences (General)
Meeting Information
Meeting: BioScience 2004
Location: Glasgow
Country: United Kingdom
Start Date: July 18, 2004
End Date: July 22, 2004
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available