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A modular suite of hardware enabling spaceflight cell culture researchBioServe Space Technologies, a NASA Research Partnership Center (RPC), has developed and operated various middeck payloads launched on 23 shuttle missions since 1991 in support of commercial space biotechnology projects. Modular cell culture systems are contained within the Commercial Generic Bioprocessing Apparatus (CGBA) suite of flight-qualified hardware, compatible with Space Shuttle, SPACEHAB, Spacelab and International Space Station (ISS) EXPRESS Rack interfaces. As part of the CGBA family, the Isothermal Containment Module (ICM) incubator provides thermal control, data acquisition and experiment manipulation capabilities, including accelerometer launch detection for automated activation and thermal profiling for culture incubation and sample preservation. The ICM can accommodate up to 8 individually controlled temperature zones. Command and telemetry capabilities allow real-time downlink of data and video permitting remote payload operation and ground control synchronization. Individual cell culture experiments can be accommodated in a variety of devices ranging from 'microgravity test tubes' or standard 100 mm Petri dishes, to complex, fed-batch bioreactors with automated culture feeding, waste removal and multiple sample draws. Up to 3 levels of containment can be achieved for chemical fixative addition, and passive gas exchange can be provided through hydrophobic membranes. Many additional options exist for designing customized hardware depending on specific science requirements.
Document ID
20050218227
Acquisition Source
Marshall Space Flight Center
Document Type
Reprint (Version printed in journal)
Authors
Hoehn, Alexander
(University of Colorado at Boulder United States)
Klaus, David M.
Stodieck, Louis S.
Date Acquired
August 23, 2013
Publication Date
March 1, 2004
Publication Information
Publication: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume: 11
Issue: 1
ISSN: 1077-9248
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NCC8-242
Distribution Limits
Public
Copyright
Other
Keywords
manned
STS Shuttle Project
ISS Project
Non-NASA Center
Flight Experiment
long duration
short duration
NASA Discipline Cell Biotechnology

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