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Multiple melanocortin receptors are expressed in bone cellsMelanocortin receptors belong to the seven transmembrane domain, G-protein coupled family of receptors. There are five members of this receptor family labeled MC1R-MC5R. These receptors are activated by fragments derived from a larger molecule, proopiomelanocortin (POMC) and include ACTH, alpha beta and gamma-MSH and beta-endorphin. Because of in vitro and in vivo data suggesting direct effects of these POMC molecules on bone and bone turnover, we examined bone and bone derived cells for the presence of the various members of the melanocortin receptor family. We report that the five known melanocortin receptors are expressed to varying degrees in osteoblast-like and osteoclastic cells. POMC fragments increased proliferation and expression of a variety of genes in osteoblastic cells. Furthermore, POMC mRNA was detected in osteoclastic cells. These data demonstrate that POMC-derived peptide hormones acting through high affinity melanocortin receptors have specific effects on bone cells. Thus, in addition to the indirect effects of POMC-derived hormones on bone turnover through their modulation of steroid hormone secretion, POMC fragments may have direct and specific effects on bone cell subpopulations.
Document ID
20050232527
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Zhong, Qing
(Institute of Molecular Medicine and Genetics Augusta, GA 30912, United States)
Sridhar, Supriya
Ruan, Ling
Ding, Ke-Hong
Xie, Ding
Insogna, Karl
Kang, Baolin
Xu, Jianrui
Bollag, Roni J.
Isales, Carlos M.
Date Acquired
August 23, 2013
Publication Date
May 1, 2005
Publication Information
Publication: Bone
Volume: 36
Issue: 5
ISSN: 8756-3282
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Musculoskeletal
Non-NASA Center

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