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Stability of chromosome aberrations in the blood lymphocytes of astronauts measured after space flight by FISH chromosome paintingFollow-up measurements of chromosome aberrations in the blood lymphocytes of astronauts were performed by FISH chromosome painting at various intervals from 5 months to more than 5 years after space flight and compared to preflight baseline measurements. For five of the six astronauts studied, the analysis of individual time courses for translocations revealed a temporal decline of yields with half-lives ranging from 10 to 58 months. The yield of exchanges remained unchanged for the sixth astronaut during an observation period of 5 months after flight. These results may indicate complications with the use of stable aberrations for retrospective dose reconstruction, and the differences in the decay time may reflect individual variability in risk from space radiation exposure.
Document ID
20050240374
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
George, K.
(Wyle Laboratories Houston, Texas 77058, United States)
Willingham, V.
Cucinotta, F. A.
Date Acquired
August 23, 2013
Publication Date
October 1, 2005
Publication Information
Publication: Radiation research
Volume: 164
Issue: 4 Pt 2
ISSN: 0033-7587
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other

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