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Aerosols in the study of convective acinar mixingConvective mixing (CM) refers to the different transport mechanisms except Brownian diffusion that irreversibly transfer inspired air into resident air and can be studied using aerosol bolus inhalations. This paper provides a review of the present understanding of how each of these mechanisms contributes to CM. Original data of the combined effect of stretch and fold and gravitational sedimentation on CM are also presented. Boli of 0.5 microm-diameter particles were inhaled at penetration volumes (V(p)) of 300 and 1200 ml in eight subjects. Inspiration was followed by a 10-s breath hold, during which small flow reversals (FR) were imposed, and expiration. There was no physiologically significant dependence in dispersion and deposition with increasing FR. The results were qualitatively similar to those obtained in a previous study in microgravity in which it was speculated that the phenomenon of stretch and fold occurred during the first breathing cycle without the need of any subsequent FR.
Document ID
20050240758
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Darquenne, Chantal
(NASA Headquarters Washington, DC United States)
Prisk, G. Kim
Date Acquired
August 23, 2013
Publication Date
August 25, 2005
Publication Information
Publication: Respiratory physiology & neurobiology
Volume: 148
Issue: 2-Jan
ISSN: 1569-9048
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: 1 R01 ES11184
Distribution Limits
Public
Copyright
Other

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