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Hydrophobic effect at aqueous interfacesConceptual basis for hydrophobic effects in bulk water and at aqueous interfaces have similar conceptual basis but often manifests itself differently. Using a wide range of computer simulations as the basis, I will review different forms of hydrophobic effects at a variety of interfaces starting from simple liquid-vapor and water-oil interfaces and progressing to water-membrane interfaces. I will start with discussing how water is organized at different interfaces, stressing both similarities and differences. The main thread is that, as in the bulk liquid, hydrophobic effects have profound influence on conformational equilibria and organization of both small molecules and macromolecules, but the result of this influence is quite different. Specifically, it will be shown that many small, but not necessarily amphiphilic molecules tend to accumulate at the interface and, and this tendency will be explained. Furthermore, I will show that many short peptides that are disordered in water spontaneously fold into well-defined structures in the interfacial environment. Biological implications of this self-organizing effect will be discussed.
Document ID
20060015639
Acquisition Source
Ames Research Center
Document Type
Preprint (Draft being sent to journal)
Authors
Pohorille, Andrew
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 23, 2013
Publication Date
January 1, 2005
Subject Category
General
Meeting Information
Meeting: Hydrophobic effect at aqueous interfaces
Location: Honolulu, HI
Country: United States
Start Date: December 15, 2005
End Date: December 20, 2005
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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