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Using Latent Sleepiness to Evaluate an Important Effect of PromethazineAstronauts often use promethazine (PMZ) to counteract space motion sickness; however PMZ may cause drowsiness, which might impair cognitive function. In a NASA ground study, subjects received PMZ and their cognitive performance was then monitored over time. Subjects also reported sleepiness using the Karolinska Sleepiness Score (KSS), which ranges from 1 - 9. A problem arises when using KSS to establish an association between true sleepiness and performance because KSS scores tend to overly concentrate on the values 3 (fairly awake) and 7 (moderately tired). Therefore, we defined a latent sleepiness measure as a continuous random variable describing a subject s actual, but unobserved true state of sleepiness through time. The latent sleepiness and observed KSS are associated through a conditional probability model, which when coupled with demographic factors, predicts performance.
Document ID
20070009877
Acquisition Source
Johnson Space Center
Document Type
Conference Paper
Authors
Feiveson, Alan H.
(NASA Johnson Space Center Houston, TX, United States)
Hayat, Matthew
Vksman, Zalman
Putcha, Laksmi
Date Acquired
August 24, 2013
Publication Date
January 1, 2007
Subject Category
Aerospace Medicine
Meeting Information
Meeting: Joint Statistical Meetings
Location: Sal Lake City, UT
Country: United States
Start Date: July 29, 2007
End Date: August 2, 2007
Sponsors: American Statistical Association
Distribution Limits
Public
Copyright
Other

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