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Risk Assessment of Radiation Exposure using Molecular BiodosimetryCurrent cytogenetic biodosimetry methods would be difficult to adapt to spaceflight operations, because they require toxic chemicals and a substantial amount of time to perform. In addition, current biodosimetry techniques are limited to whole body doses over about 10cGy. Development of new techniques that assess radiation exposure response at the molecular level could overcome these limitations and have important implications in the advancement of biodosimetry. Recent technical advances include expression profiling at the transcript and protein level to assess multiple biomarkers of exposure, which may lead to the development of a radiation biomarker panel revealing possible fingerprints of individual radiation sensitivity. So far, many biomarkers of interest have been examined in their response to ionizing radiation, such as cytokines and members of the DNA repair pathway. New technology, such as the Luminex system can analyze many biomarkers simultaneously in one sample.
Document ID
20070010670
Acquisition Source
Johnson Space Center
Document Type
Conference Paper
Authors
Elliott, Todd F.
(Wyle Labs., Inc. Houston, TX, United States)
George, K.
(Wyle Labs., Inc. Houston, TX, United States)
Hammond, D. K.
(Enterprise Advisory Services, Inc. Houston, TX, United States)
Cucinotta, F. A.
(NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 23, 2013
Publication Date
January 1, 2007
Subject Category
Aerospace Medicine
Meeting Information
Meeting: ICRR Annual Meeting
Location: San Francisco, CA
Country: United States
Start Date: July 8, 2007
End Date: July 12, 2007
Sponsors: International Congress of Radiation Research
Distribution Limits
Public
Copyright
Other

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