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Low Magnitude Mechanical Signals Reduce Risk-Factors for Fracture during 90-Day Bed RestLong duration spaceflight leads to multiple deleterious changes to the musculoskeletal system, where loss of bone density, an order of magnitude more severe than that which follows the menopause, combined with increased instability, conspire to elevate the risk of bone fracture due to falls on return to gravitational fields. Here, a ground-based analog for spaceflight is used to evaluate the efficacy of a low-magnitude mechanical intervention, VIBE (Vibrational Inhibition of Bone Erosion), as a potential countermeasure to preserve musculoskeletal integrity in the face of disuse. Twenty-six subjects consented to ninety days of six-degree head-down tilt bed-rest. 18 completed the 90d protocol, 8 of which received daily 10-minute exposure to 30 Hz, 0.3g VIBE, applied in the supine position using a vest elastically coupled to the vibrating platform. The shoulder harness induced a load of 60% of the subjects body weight. At baseline and 90d, Qualitative Ultrasound Scans (QUS) of the calcaneus and CT-scans of the hip and spine were performed to measure changes in bone density. Postural control (PC) was assessed through center of pressure (COP) recordings while subjects stood on a force platform for 4 minutes of quiet stance with eyes closed, and again with eyes opened. As compared to control bedrest subjects,
Document ID
20070022326
Acquisition Source
Johnson Space Center
Document Type
Conference Paper
Authors
Muir, J. W.
(State Univ. of New York Stony Brook, NY, United States)
Xia, Y.
(State Univ. of New York Stony Brook, NY, United States)
Holquin, N.
(State Univ. of New York Stony Brook, NY, United States)
Judex, S.
(State Univ. of New York Stony Brook, NY, United States)
Qin, Y.
(State Univ. of New York Stony Brook, NY, United States)
Evans, H.
(NASA Johnson Space Center Houston, TX, United States)
Lang, T.
(California Univ. San Francisco, CA, United States)
Rubin, C.
(State Univ. of New York Stony Brook, NY, United States)
Date Acquired
August 23, 2013
Publication Date
January 1, 2007
Subject Category
Aerospace Medicine
Report/Patent Number
07-A-1976-ASBMR
Meeting Information
Meeting: American Society for Bone and Mineral Research Meeting
Location: Honolulu, HI
Country: United States
Start Date: September 16, 2007
End Date: September 19, 2007
Funding Number(s)
CONTRACT_GRANT: NRA-03-OBRP-06
Distribution Limits
Public
Copyright
Other

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