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Modular and Stochastic Approaches to Molecular Pathway Models of ATM, TGF beta, and WNT SignalingDeterministic pathway models that describe the biochemical interactions of a group of related proteins, their complexes, activation through kinase, etc. are often the basis for many systems biology models. Low dose radiation effects present a unique set of challenges to these models including the importance of stochastic effects due to the nature of radiation tracks and small number of molecules activated, and the search for infrequent events that contribute to cancer risks. We have been studying models of the ATM, TGF -Smad and WNT signaling pathways with the goal of applying pathway models to the investigation of low dose radiation cancer risks. Modeling challenges include introduction of stochastic models of radiation tracks, their relationships to more than one substrate species that perturb pathways, and the identification of a representative set of enzymes that act on the dominant substrates. Because several pathways are activated concurrently by radiation the development of modular pathway approach is of interest.
Document ID
20090024208
Acquisition Source
Johnson Space Center
Document Type
Conference Paper
Authors
Cucinotta, Francis A.
(NASA Johnson Space Center Houston, TX, United States)
O'Neill, Peter
(Oxford Univ. Oxford, United Kingdom)
Ponomarev, Artem
(Universities Space Research Association Houston, TX, United States)
Carra, Claudio
(Universities Space Research Association Houston, TX, United States)
Whalen, Mary
(California Univ., Lawrence Berkeley National Lab. Berkeley, CA, United States)
Pluth, Janice M.
(California Univ., Lawrence Berkeley National Lab. Berkeley, CA, United States)
Date Acquired
August 24, 2013
Publication Date
April 6, 2009
Subject Category
Life Sciences (General)
Report/Patent Number
JSC-18076
Meeting Information
Meeting: Low Dose Workshop
Location: Bethesda, MD
Country: United States
Start Date: April 6, 2009
Distribution Limits
Public
Copyright
Other

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