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Effects of X-ray irradiation on human spermatogenesisDirect cell kill and inhibition of mitosis have been suggested as mechanisms to explain the occurrence of absolute sterility following the irradiation of the testes. In order to obtain information on the existence and dose dependency of the mechanisms for man, a controlled study was initiated. Sixty-four men received a single midorgan dose to both of their testes ranging from 7.5 to 400r (f = .95). It was deduced from resulting pre-sterile period and sterile period data that both cell kill and mitosis halting mechanisms were operating. The maximum observed sterile period was 501 days with eventual recovery observed in each individual where the follow-up was complete. Thus man appears to be highly radiosensitive in regard to temporary sterility but quite radioresistant in regard to permanent sterility.
Document ID
19720009980
Document Type
Conference Paper
Authors
Thorslund, T. W. (Washington Univ. Seattle, WA, United States)
Paulsen, C. A. (Washington Univ. Seattle, WA, United States)
Date Acquired
August 6, 2013
Publication Date
January 1, 1972
Publication Information
Publication: NASA, Washington Proc. of the Natl. Symp. on Nat. and Manmade Radiation in Space
Subject Category
BIOSCIENCES
Funding Number(s)
CONTRACT_GRANT: AT(45-1)-2225
CONTRACT_GRANT: AT(45-1)-1781
CONTRACT_GRANT: AM-05161
CONTRACT_GRANT: AM-05436
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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IDRelationTitle19720009951Analytic PrimaryProceedings of the National Symposium on Natural and Manmade Radiation in Space