Effects of Centrifuge Diameter and Operation on Rodent Adaptation to Chronic Centrifugation

This study examined the responses of rats to centrifugation in a constant acceleration field (1.5 G). Centrifuge diameter (1.8m, 2.5m or 6.0m) and schedule of operation (Daily or weekly stop) varied between groups. Body mass, food consumption, water consumption and neurovestibular function were measured weekly. Body temperature and activity were continuously monitored using telemetry. A subset of subjects were videotaped (50 minutes per day) to allow for movement analysis. Exposure to a hyperdynamic field of this magnitude did cause the expected depression in the physiological variables monitored. Recovery was accomplished within a relatively rapid time frame; all variables returned to precentrifugation levels. In general, the magnitudes of the changes and the rate of recovery were similar at different centrifuge diameters and stopping frequency. There were cases, however, in which the magnitude of the response and/or the rate of recovery to a new steady-state were altered as a result of centrifuge diameter. In summary, these results indicate that stopping frequency has little, if any, effect on adaptation to chronic centrifugation. However, the angular velocity (omega), and therefore centrifuge diameter is an important consideration in the adaptation of an organism to chronic centrifugation.