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Combining Flux Balance and Energy Balance Analysis for Large-Scale Metabolic Network: Biochemical Circuit Theory for Analysis of Large-Scale Metabolic NetworksPredicting behavior of large-scale biochemical metabolic networks represents one of the greatest challenges of bioinformatics and computational biology. Approaches, such as flux balance analysis (FBA), that account for the known stoichiometry of the reaction network while avoiding implementation of detailed reaction kinetics are perhaps the most promising tools for the analysis of large complex networks. As a step towards building a complete theory of biochemical circuit analysis, we introduce energy balance analysis (EBA), which compliments the FBA approach by introducing fundamental constraints based on the first and second laws of thermodynamics. Fluxes obtained with EBA are thermodynamically feasible and provide valuable insight into the activation and suppression of biochemical pathways.
Document ID
20020043150
Acquisition Source
Ames Research Center
Document Type
Preprint (Draft being sent to journal)
Authors
Beard, Daniel A.
(Washington Univ. Seattle, WA United States)
Liang, Shou-Dan
(NASA Ames Research Center Moffett Field, CA United States)
Qian, Hong
(Washington Univ. Seattle, WA United States)
Biegel, Bryan
Date Acquired
September 7, 2013
Publication Date
August 11, 2001
Subject Category
Life Sciences (General)
Funding Number(s)
PROJECT: RTOP 704-40-32
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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