NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Persistent Expression Changes of Fibrosis Related Genes in the Lung Tissues of Rats Exposed to Lunar Dust ParticlesThe Moon's surface is covered by a layer of reactive dust, containing 1-2% of respirable fine dust (< 3 microns). The habitable area of any lunar landing vehicle would inevitably be contaminated with lunar dust that could pose a health risk. The purpose of the study is to evaluate the toxicity of Apollo moon dust in rodents through inhalation to assess the health risk of dust exposures to humans and to identify the mechanisms and potential pathways involved in lunar dust-induced toxicity. Ccl3, Ccl12, Cxcl2, Cxcl5, Itgb8, Tnf, Ldhc, Clec4e, Bmp7, and Smad6, showed persistently significant expression changes in the lung tissue. The expression of several of these genes were dose- and time- dependent, and were significantly correlated with other pathological. Our previous data showed that no pathological changes were detected in low dose groups. However, several genes, primarily produced by lung epithelial, were significantly altered persistently in response to low-dose dust exposure. The data presented in this study, for the first time, explores the molecular mechanisms of lunar dust induced toxicity, contributing not only the risk assessment for future space exploration, but also understandings of the dust-induced toxicity to humans on earth.
Document ID
20140007371
Document Type
Presentation
Authors
Zhang, Ye (Wyle Integrated Science and Engineering Group Houston, TX, United States)
Lam, Chiu-Wing (Wyle Integrated Science and Engineering Group Houston, TX, United States)
Scully, Robert R. (Wyle Integrated Science and Engineering Group Houston, TX, United States)
Theriot, Corey (Texas Univ. Galveston, TX, United States)
Zalesak, Selina (Texas Univ. Galveston, TX, United States)
Yeshitla, Samrawit (NASA Johnson Space Center Houston, TX, United States)
Williams, Kyle (Texas Southern Univ. Houston, TX, United States)
Wu, Honglu (NASA Johnson Space Center Houston, TX, United States)
James, John T. (NASA Johnson Space Center Houston, TX, United States)
Date Acquired
June 13, 2014
Publication Date
February 12, 2014
Subject Category
Life Sciences (General)
Lunar and Planetary Science and Exploration
Report/Patent Number
JSC-CN-30489
Meeting Information
NASA Human Research Program Investigators'' Workshop (HRP 2014)(Galveston, TX)
Distribution Limits
Public
Copyright
Public Use Permitted.

Available Downloads

NameType 20140007371.pdf STI

Related Records

IDRelationTitle20140011881See AlsoPersistent Expression Changes of Fibrosis-Related Genes in the Lung Tissues of Rats Exposed to Lunar Dust Particles