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The BioSentinel Bioanalytical Microsystem: Characterizing DNA Radiation Damage in Living Organisms Beyond Earth OrbitWe will present details and initial lab test results from an integrated bioanalytical microsystem designed to conduct the first biology experiments beyond low Earth orbit (LEO) since Apollo 17 (1972). The 14-kg, 12x24x37-cm BioSentinel spacecraft (Figure 1) assays radiation-responsive yeast in its science payload by measuring DNA double-strand breaks (DSBs) repaired via homologous recombination, a mechanism common to all eukaryotes including humans. S. cerevisiae (brewer's yeast) in 288 microwells are provided with nutrient and optically assayed for growth and metabolism via 3-color absorptimetry monthly during the 18-month mission. BioSentinel is one of several secondary payloads to be deployed by NASA's Exploration Mission 1 (EM-1) launch vehicle into approximately 0.95 AU heliocentric orbit in July 2018; it will communicate with Earth from up to 100 million km.
Document ID
20160007343
Document Type
Conference Paper
Authors
Ricco, A. J. (Dublin City Univ. Dublin, Ireland)
Hanel, R. (NASA Ames Research Center Moffett Field, CA United States)
Bhattacharya, S. (NASA Ames Research Center Moffett Field, CA United States)
Boone, T. (Millennium Engineering and Integration Co. Moffett Field, CA, United States)
Tan, M. (Millennium Engineering and Integration Co. Moffett Field, CA, United States)
Mousavi, A. (Stanford Univ. Stanford, CA, United States)
Rademacher, A. (Millennium Engineering and Integration Co. Moffett Field, CA, United States)
Schooley, A. (Millennium Engineering and Integration Co. Moffett Field, CA, United States)
Klamm, B. (NASA Ames Research Center Moffett Field, CA United States)
Benton, J. (Wyle Labs., Inc. Moffett Field, CA, United States)
Padgen, M. (Millennium Engineering and Integration Co. Moffett Field, CA, United States)
Gentry, D. (NASA Ames Research Center Moffett Field, CA United States)
Friedericks, C. (NASA Ames Research Center Moffett Field, CA United States)
Defouw, G. (SGT, Inc. Moffett Field, CA, United States)
Parra, M. (Wyle Labs., Inc. Moffett Field, CA, United States)
Santa Maria, S. (Wyle Labs., Inc. Moffett Field, CA, United States)
Marina, D. (Wyle Labs., Inc. Moffett Field, CA, United States)
Swan, B. G. (NASA Johnson Space Center Houston, TX, United States)
Wheeler, S. (NASA Johnson Space Center Houston, TX, United States)
Gavalas, S. (NASA Johnson Space Center Houston, TX, United States)
Lewis, B. (NASA Ames Research Center Moffett Field, CA United States)
Sanchez, H. (NASA Ames Research Center Moffett Field, CA United States)
Chartres, J. (Millennium Engineering and Integration Co. Moffett Field, CA, United States)
Lusby, T. (Millennium Engineering and Integration Co. Moffett Field, CA, United States)
Date Acquired
June 8, 2016
Publication Date
June 5, 2016
Subject Category
Aerospace Medicine
Space Radiation
Report/Patent Number
ARC-E-DAA-TN30932
Paper ID No 0092
Meeting Information
Hilton Head Workshop 2016: A Solid State Sensors, Actuators, and Microsystems Workshop(Hilton Head Island, SC)
Funding Number(s)
CONTRACT_GRANT: NNA14AB82C
CONTRACT_GRANT: NNA13AC87C
Distribution Limits
Public
Copyright
Public Use Permitted.
Keywords
BioSentinel
Bioanalytical Microsystem
Radiation Damage

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