Effects of Prolonged Exposure to Pure Oxygen on Human Performance

In view of the pure oxygen atmosphere selected for Project Mercury, and in anticipation of subsequent manned space missions of increasing duration, it was apparent that there was a need to obtain more extensive physiological data on the prolonged effects of pure oxygen environments on the crews.

This study, conducted by Republic Aviation Corporation under Contract NASR-92, was initiated in collaboration with General Charles Roadman, USAF (MC), Director of Aerospace Medicine (formerly the Office of Life Sciences, NASA Headquarters), and his staff in an effort to provide a greater breadth of
scientific data on the prolonged effects of such an environment on human performance.

Although the 5 psi environment of Project Mercury was the focal point of the study, a broader appraisal of the effects of pure oxygen in the absence of nitrogen was attempted by including studies at 7.4 psi and 3.8 psi in addition to a control group at sea level atmospheric conditions.

After award of the contract, the technical monitoring of the study was provided by the Manned Spacecraft Center, Houston, Texas, where Mr. Edward Michel served as monitor and coordinator for these and related studies subsequently established in laboratories of the U.S. Navy and U. S. Air Force.